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Unexplained Chest Pain
Chest Wall Causes & Treatment

When chest pain has been investigated and the heart and lungs have been cleared, a chest wall cause is the most likely explanation — costochondritis, Tietze syndrome, slipped rib syndrome, thoracic outlet syndrome, or focal nerve pain from the rib. Patients describe these as ‘a stabbing pain when I breathe,’ ‘a tender spot on my rib,’ ‘a clicking under my ribs,’ or ‘pain that won’t go away.’ The diagnosis is usually made at the bedside, not on a scan. Dr Lawrence Okiror, Consultant Thoracic and Robotic Surgeon (GMC 6150382), reviews chest wall pain personally at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 days. Self-referrals welcome.

Last reviewed: May 2026 · Dr Lawrence Okiror FRCS(CTh) FRCSEd(CTh) · GMC 6150382

Most Is Chest Wall

After heart and lungs have been cleared, the most likely source is the chest wall — ribs, costal cartilage, intercostal nerves, or the joints where ribs meet the spine and breastbone. Common, benign, and treatable.

Diagnosed at the Bedside

A focused chest wall examination — how the pain reproduces with palpation, with movement, with the hooking manoeuvre — discriminates the common causes within minutes. Imaging confirms; it does not lead.

Specific Treatments

Each cause has a specific treatment. Most resolve with conservative management. Some — slipped rib syndrome, thoracic outlet syndrome, persistent intercostal schwannoma — have an effective surgical option when conservative measures fail.

Examination decides, imaging confirms

Most chest wall pain comes from soft tissue, joints, and nerves — structures that imaging shows poorly. The discrimination between the common causes is at the bedside, not on the scan. The hooking manoeuvre under the costal margin is the test for slipped rib syndrome — a positive hook reproduces the pain. Reproducible tenderness over multiple costochondral junctions, without visible swelling, is costochondritis. The same pattern at a single junction with visible or palpable swelling is Tietze syndrome. Specific provocation tests reproduce thoracic outlet syndrome. A pinpoint tender spot along the line of one rib points to focal intercostal nerve pain — sometimes a schwannoma.

The CT may be normal in any of these. Examination decides; imaging confirms. Dr Okiror examines the chest wall personally at the first appointment, applies the specific manoeuvres, and discusses the differential and the plan in plain language. Private appointments at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 working days. Self-referrals welcome.

  1. Most chest wall pain is benign.Costochondritis, Tietze syndrome, and slipped rib syndrome together account for the majority of musculoskeletal chest wall pain. None is dangerous; all are treatable.
  2. The diagnosis is made at the bedside.Bedside palpation, the hooking manoeuvre, and the pattern of pain on movement discriminate the common causes. Imaging confirms specific suspicions; it does not lead the diagnosis.
  3. Specific causes have specific treatments.Costochondritis usually settles with conservative management. Slipped rib syndrome — often misattributed to reflux — has a specific operation that resolves the pain. Thoracic outlet syndrome has its own surgical pathway. Schwannoma may need removal.
  4. Some patterns warrant imaging.Pain that is constant rather than movement-related, that wakes the patient at night, that is associated with weight loss, or that follows trauma, deserves a CT. Imaging is targeted, not reflexive.
  5. You are seen quickly and a clear plan is made.Private appointments at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 days. Most patients leave the first appointment with a confident diagnosis and a plan.

Costochondritis, Tietze,
and Slipped Rib Syndrome

All three are common causes of chest wall pain. They are easy to confuse from history alone but easy to discriminate at the bedside.

Feature Costochondritis Tietze Syndrome Slipped Rib Syndrome
Where Multiple costochondral junctions, often upper ribs Single junction, usually 2nd or 3rd rib Lower ribs (8th, 9th, 10th), where they connect to the cartilage above
Visible swelling No Yes — visible or palpable swelling at the affected joint No
Hooking manoeuvre Negative Negative Positive — reproduces the pain
Often follows Sometimes a viral illness; often unclear A viral illness or unaccustomed exertion Movement, twisting, deep breathing, often after trauma
First-line management Conservative — anti-inflammatories, time Conservative — anti-inflammatories, time Targeted physiotherapy
Surgery role No No Yes — cartilage excision and rib stabilisation when conservative measures fail

The hooking manoeuvre — a finger placed under the costal margin and pulled gently outward — is the single most useful bedside test for slipped rib syndrome. A positive hook reproduces the pain.

What Patients Describe
and What Each One Is

Patients describe these as ‘a stabbing pain when I breathe,’ ‘a tender spot on my rib,’ ‘a clicking under my ribs,’ ‘an ache that won’t go away,’ or ‘pain into my arm and shoulder.’ Different patterns point to different causes.

Often Misdiagnosed

Slipped Rib Syndrome

A condition where the cartilage that connects the lower ribs (8th, 9th, 10th) loses its normal stability, allowing the rib tip to slip and irritate the intercostal nerve underneath. Pain is typically lower chest or upper abdomen, often misattributed to reflux, gallbladder problems, or musculoskeletal back pain. Many patients have seen multiple specialists before the diagnosis is made.

Diagnosis is by the hooking manoeuvre. Conservative management with targeted physiotherapy is first-line; surgery (cartilage excision and rib stabilisation) is highly effective when conservative measures fail. More on slipped rib syndrome →

Common — Inflammation

Costochondritis & Tietze Syndrome

Both involve inflammation at the costochondral junctions — where the ribs meet the breastbone. Costochondritis affects multiple junctions, often upper ribs, with no visible swelling. Tietze syndrome affects a single junction (most often the 2nd or 3rd rib) with visible or palpable swelling at that point.

Both are benign and usually settle with anti-inflammatories and time. Neither needs surgery. Reassurance from a confident bedside diagnosis is part of the treatment, because the pain can be intense and many patients have been worried about a heart problem.

Pain into the Arm

Thoracic Outlet Syndrome

A group of conditions where the nerves and blood vessels passing between the collarbone and the first rib become compressed. The pain pattern is usually arm, shoulder, neck, or upper chest, often with tingling, weakness, or colour change in the hand. Specific provocation tests reproduce the symptoms at the bedside.

When confirmed and conservative management fails, surgical decompression (first rib resection) resolves the symptoms in the majority of patients. More on thoracic outlet syndrome →

Focal Nerve Pain

Schwannoma an intercostal nerve sheath tumour

A schwannoma is a benign tumour growing from the protective sheath around a nerve. When it arises from an intercostal nerve, it causes focal pain or tingling along the line of a single rib, sometimes with a small lump that can be felt between the ribs. The pain is well-localised, often described as a pinpoint tender spot, and may be reproduced by pressing on the same place each time.

MRI is the imaging investigation of choice. Removal — usually by robotic keyhole surgery, with the patient home within 24–48 hours — is offered when the pain is persistent, when the lesion is growing, or when the diagnosis needs to be confirmed. More on schwannoma →

Post-Trauma or Stress

Rib Fractures & Stress Injury

Rib fractures cause sharp, well-localised pain that worsens with deep breathing, coughing, or movement. Stress fractures — particularly in runners, rowers, golfers, and those with chronic cough — can cause similar pain without a clear trauma history and are sometimes invisible on a chest X-ray.

Most heal with rest. Where multiple displaced fractures or a flail segment is present, surgical fixation (SSRF) is sometimes appropriate. More on rib fracture fixation →

Pleural & Pulmonary

Pleural and Pulmonary Pain

Pain from the lining of the lungs (the pleura) is sharp, worse on deep breathing, and often felt to one side of the chest. It can follow pneumonia, pleural effusion, pneumothorax, or pulmonary embolism — conditions that warrant imaging and often urgent assessment. Where pleural pain is suspected, a chest X-ray and CT are the appropriate first steps.

Patterns That Warrant
a CT Scan

Most chest wall pain does not need imaging. The features below are the signal that a scan is the next step.

Pattern What It May Suggest First Investigation
Constant pain, not movement-related Possible nerve, bone, or pleural pathology rather than musculoskeletal CT chest
Pain that wakes the patient at night Same — not a typical pattern for benign chest wall pain CT chest
Pain with weight loss Possible underlying tumour — primary rib lesion or metastatic deposit CT chest
Pain after significant trauma Possible rib fracture or pulmonary contusion CT chest
Pain with a lump See chest wall lump pathway Chest wall lump →
Pain with shortness of breath Possible pleural pathology — effusion, pneumothorax, embolism CT chest, often urgently
Pain into arm, shoulder, or neck Possible thoracic outlet syndrome TOS pathway →

Two London Hospitals,
Both with Robotic Surgery

Outpatient assessment and any subsequent surgery for chest wall pain take place at London Bridge Hospital or The Lister Hospital Chelsea. Both hospitals have the operating theatre infrastructure for keyhole and robotic chest wall surgery. London Bridge Hospital is the primary base for more complex cases, including thoracic outlet syndrome surgery and intercostal schwannoma resection. The Lister Chelsea is the second operating base, suitable for many slipped rib syndrome operations and for follow-up appointments depending on convenience.

First-appointment consultations and follow-up appointments are also available at the HCA outpatient clinics in Canary Wharf and the City of London. Surgery and overnight care take place at London Bridge Hospital or The Lister Chelsea.

Should I worry about chest pain that’s been investigated?

If your heart and lungs have already been cleared, the most likely source is the chest wall — and that is reassuring. Most chest wall pain is benign and treatable. What matters next is a focused chest wall examination to identify which specific cause is responsible.

Why hasn’t a scan shown the cause?

Most chest wall pain is from soft tissue, joints, or nerves — structures that imaging shows poorly. A normal CT does not exclude a chest wall cause; it just confirms there is nothing visibly wrong with the lungs, the airways, or the bones. The diagnosis is made at the bedside.

What will the appointment involve?

A focused history of how the pain behaves, followed by a chest wall examination — palpation of the costochondral junctions, the hooking manoeuvre under the lower ribs, provocation tests for thoracic outlet syndrome, and assessment of any focal tender spots. Most patients leave with a confident diagnosis and a plan in 30 minutes.

Do I need a GP referral?

Self-referrals welcome — no GP letter needed before booking. Private appointments at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 days. Bring any existing imaging or cardiac workup results. New consultations from £250. Most major insurers accepted.

Questions About
Chest Wall Pain

Questions most commonly asked by patients with chest pain that has been investigated and where the heart and lungs have been cleared.

Book an Assessment →

Or call Jo Mitchelson:
020 7952 2882

My heart and lungs have been cleared — what causes chest pain that nobody can find a reason for?
In most cases, the cause is the chest wall itself — the ribs, costal cartilage, intercostal muscles, or intercostal nerves. Costochondritis, Tietze syndrome, slipped rib syndrome, thoracic outlet syndrome, and focal intercostal nerve pain together account for the majority of unexplained chest pain after cardiac and respiratory causes have been ruled out. Each has a different bedside pattern and a different treatment, which is why a careful chest wall examination is the next step.
How is the cause diagnosed if scans were normal?
At the bedside. The pattern of pain on movement, the location of tenderness, the response to specific manoeuvres (the hooking manoeuvre for slipped rib, palpation of the costochondral junctions for costochondritis and Tietze, provocation tests for thoracic outlet syndrome), and the relationship to a specific intercostal nerve all discriminate the common causes. Imaging confirms specific suspicions — a normal CT does not exclude chest wall pain because most chest wall pain is from soft tissue, joints, and nerves that CT shows poorly. Examination decides; imaging confirms.
What is slipped rib syndrome?
A condition where the cartilage that connects the lower ribs (8th, 9th, 10th) loses its normal stability, allowing the rib tip to slip and irritate the intercostal nerve underneath. It causes lower chest or upper abdominal pain, often misattributed to reflux or gallbladder problems. Diagnosis is by the hooking manoeuvre — a finger hooked under the costal margin reproduces the pain. Targeted physiotherapy is first-line; surgery (cartilage excision and rib stabilisation) is highly effective when conservative management fails. More on slipped rib syndrome →
What is the difference between costochondritis and Tietze syndrome?
Both involve inflammation at the joint between rib and breastbone (the costochondral junction), but the pattern differs. Costochondritis affects multiple junctions, often upper ribs, and there is no visible swelling. Tietze syndrome typically affects a single costochondral junction (most often the 2nd or 3rd rib) with visible or palpable swelling at that point. Both are benign and usually settle with anti-inflammatories and time. Neither needs surgery.
What is thoracic outlet syndrome?
A group of conditions where the nerves and blood vessels passing between the collarbone and the first rib become compressed. The pain pattern is usually arm, shoulder, neck, or upper chest, often with tingling, weakness, or colour change in the hand. Specific provocation tests reproduce the symptoms at the bedside. When confirmed and conservative management fails, surgical decompression (first rib resection) resolves the symptoms in the majority of patients. More on thoracic outlet syndrome →
Can a schwannoma cause chest pain?
Yes. A schwannoma is a benign tumour growing from the protective sheath around a nerve. When it arises from an intercostal nerve, it can cause focal pain or tingling along the line of a single rib, sometimes with a lump that can be felt between the ribs. MRI is the imaging investigation of choice. Removal — usually by robotic keyhole surgery — is offered when the pain is persistent, when the lesion is growing, or when the diagnosis needs to be confirmed. More on schwannoma →
Which features in chest wall pain warrant imaging?
Pain that is constant rather than movement-related, pain that wakes the patient from sleep, pain associated with weight loss, pain after significant blunt trauma, pain with a lump, or pain with shortness of breath, all warrant imaging. A CT chest is usually the appropriate first investigation. Most patients with movement-related chest wall tenderness, no red flags, and a confident bedside diagnosis do not need a scan.
Could the pain be coming from a rib fracture I didn’t know about?
Possible. Stress fractures of the ribs — particularly in runners, rowers, golfers, and those with chronic cough — can cause chest wall pain that does not show on a chest X-ray. Bone scan or CT is more sensitive. Most heal with rest. Where multiple displaced fractures or a flail segment is present, surgical fixation (SSRF) is sometimes appropriate.
Could chest pain be the only sign of something more serious?
Uncommonly. The vast majority of unexplained chest pain after cardiac and respiratory work-up is musculoskeletal in origin and not dangerous. However, primary rib tumours, metastatic deposits in a rib, or pleural pathology can present with chest wall pain alone. The red flag features above (constant pain, night pain, weight loss) are the signal that imaging is the next step. Where any concern arises, the case is discussed with the chest multidisciplinary team at London Bridge Hospital.
Do I need a GP referral?
Self-referrals welcome — no GP letter needed before booking. Private appointments at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 days. Bring any existing imaging — chest X-ray, CT, or cardiac workup results. New consultations from £250. Most major insurers accepted.

A confident diagnosis
and a clear plan, in one visit.

Self-referrals welcome. Private appointments at London Bridge Hospital and The Lister Hospital Chelsea within 2–3 days. Dr Okiror examines the chest wall personally and discusses the differential and treatment options at the first appointment.

Book an Assessment → Second Opinion

Jo Mitchelson, Designated Medical PA  · 020 7952 2882 · pa@lungsurgeon.co.uk

St Thomas’ Hospital #1 UK · Guy’s Hospital #2 UK · London Bridge Hospital #10 UK · Newsweek World’s Best Hospitals 2026

Continue Reading

Chest Wall LumpFor patients who can feel a lump rather than just pain — lipoma, schwannoma, lung hernia, benign rib lesions, and tumours. Slipped Rib SyndromeThe full clinical guide — diagnosis by the hooking manoeuvre, conservative management, and surgical repair. Thoracic Outlet SyndromeCompression of nerves and vessels at the thoracic outlet — arm, shoulder, neck, sometimes chest pain. Surgical pathway. Rib Fracture FixationSurgical stabilisation of rib fractures (SSRF) for displaced multiple fractures, flail chest, or persistent fracture pain. Shadow Found on Lung ScanFor patients whose CT shows a shadow on the lung — what it means and the surgical pathway when it’s indicated. Pleural DiseaseWhen pain is from the lining of the lungs rather than the chest wall — pleural effusion, pneumothorax, and pleural pathology. Hyperhidrosis SurgeryFor patients with excessive sweating — the surgical pathway by VATS sympathectomy when conservative measures fail. Specialist Second OpinionIndependent review of imaging, prior assessments, and treatment plans before committing to a course of action.
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